A Novel Flavonoid Glucoside from the Fruits of Lycium ruthenicun.
نویسندگان
چکیده
A novel flavonoid glucoside, ruthenicunoid A (1), together with eight known substances, were isolated from the fruits of Lycium ruthenicun Murr. Their structures were elucidated by extensive spectroscopic data and chemical methods. Especially, the absolute configuration of glucose residue in 1 was assigned by acid hydrolysis followed by derivatization and GC analysis. Biological evaluation towards Sirtuin 1 (SIRT1) found that compounds 1 and 2 exhibit inhibitory activity against SIRT1 in a concentration-dependent manner, indicating its potential on SIRT1-associated disorders.
منابع مشابه
Functional Characterization of a Flavonoid Glycosyltransferase in Sweet Orange (Citrus sinensis)
Fruits of sweet orange (Citrus sinensis), a popular commercial Citrus species, contain high concentrations of flavonoids beneficial to human health. These fruits predominantly accumulate O-glycosylated flavonoids, in which the disaccharides [neohesperidose (rhamnosyl-α-1,2-glucose) or rutinose (rhamnosyl-α-1,6-glucose)] are linked to the flavonoid aglycones through the 3- or 7-hydroxyl sites. T...
متن کاملBio-utilization of wild berries for preparation of high valued herbal wines
The fruits of wild berries, viz. Berberis lycium Royle, Pyrus pashia Buch.-Ham ex D. Don, Actinidia deliciosa (A.Chev.) C. F. Liang & A. R. Ferguson, Syzygium jambos (L.) Alston, Emblica officinalis Gaertn., Prunus cerasoides D. Don, Rubus ellipticus Sm, Crataegus sp. and Citrus karma Raf. were collected from the forests of various regions of Kangra, Himachal Pradesh (India) for preparation of ...
متن کاملFlavonoids from the leaves of Iranian Linden; Tilia rubra subsp. caucasica
Background and objectives: Plants belonging to the genus Tilia L. (Tiliaceae) are often tall beautiful trees which are considered for various medicinal potentials of their flowers and leaves. The present study was an attempt to investigate the phytochemical constituents of Tilia rubra subsp. caucasica leaves from the hyrcanian forests of north of Iran. Methods: Chroma...
متن کاملFlavonoid and a rare benzophenone glycoside from the leaves of Aquilaria sinensis.
From the leaves of Aquilaria sinensis (LOUR.) GILG, a novel benzophenone glucoside, designated as aquilarinoside A (1), and a new flavonoid, as 7-beta-D-glucoside of 5-O-methylapigenin (2), along with eight known compounds (3-10) were isolated. The structures of 1 and 2 were fully characterized by spectroscopic methods (1D, 2D NMR and MS) and the relative stereochemistry was assigned based on n...
متن کاملStructural relationship and binding mechanisms of five flavonoids with bovine serum albumin.
Flavonoids are structurally diverse and the most ubiquitous groups of dietary polyphenols distributed in various fruits and vegetables. In this study, the interaction between five flavonoids, namely formononetin-7-O-β-D-glucoside, calycosin- 7-O-β-D-glucoside, calycosin, rutin, and quercetin, and bovine serum albumin (BSA) was investigated by fluorescence and UV-vis absorbance spectroscopy. In ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Molecules
دوره 23 2 شماره
صفحات -
تاریخ انتشار 2018